Promoter
EF1a.
Reporter
SEAP.
Selection
Blasticidin.
Species
Human/Mouse.
Serotype
VSV-G.
Application
Monitor IFNα-induced activity and activation of the JAK/STAT pathway by detecting ISRE activation, or use as a screening tool for identification of activators/inhibitors of the JAK/STAT signaling pathway. The fluorescent reporter enables convenient readout using flow cytometry, fluorescence microscopy, etc. Stimulator of Interferon Genes (STING) plays a crucial role in cytosolic DNA sensing and the induction of interferon (IFN). As a result, extensive efforts have been made to elucidate the molecular mechanism of STING activation, its physiological function, and its potential as a therapeutic target for a variety of immune-related diseases. The ISRE reporter can also be used to study STING pathway (Fig.2).